Tag Archive: irritability


I was checking out the FDA website for something and I came across an article about the new drugs recently approved.

Lupron44

Eligard43

Lupron Depot45

Lupron Depot46

Viadur50

They were all approved on January 20, 2011. They are all made out of leuprolide acetate the same drug Lupron Depot that shut my body down in 2000, now they are bringing it out under different names. (see information on Lupron below).

I was looking through some old paperwork and came across a letter I had written about my experience with the prescription drug Lupron, leuprolide acetate. Here is my story I wrote just after taking Lupron in 2000, thank god we forget pain:

On January 2000, I went to my gynecologist. He diagnosed me with a cyst on my ovary. He said that the drug Lupron would shrink the cyst and I could avoid surgery. I asked about the side effects, he said it was only hot flashes and temporary menopause, but all goes away after the drug is done. He made it sound like a picnic. I thought that the drug was the way to go, sounded like no big deal and to avoid an operation again, why not? (I had my ovary removed surgically when I was 18 due to a cyst).

He gave me a 3 month dose Jan 13, 2000 or 11.25 mg of Lupron Depot in an injection form. Approximately 4 or 5 days later my skin started to crawl throughout my whole body, permanently day after day, creeping through my skin like waves of bugs crawling. I began to have trouble breathing, and was unable to get moving. I went to two different doctors,  was given a prescription by one, told to quit smoking by another. I did both but neither seemed to help.

We had went out to dinner one night because we had pre-arranged it with friends (yes that’s me, didn’t want to wreck anybodies plans even though I was in anaphylactic shock, I am a pretty tough soul!). While I was sitting there all of a sudden it felt like bubbles of liquid going into each of my lower front ribs, one at a time like dominos, then it crept it’s way up throughout my ribs in my whole chest and stayed as severe pain. My chest was crushing with chest pain, and I was having trouble breathing. I felt drained and sick all over and very pale. I laid on the couch for days, not being able to do anything and the pain was only getting worse.

I finally went to the hospital because I knew it was serious and out of my hands. They put me on a heart monitor and admitted me right away. My heart was either beating at 41 bpm. or erratically all over the place. All they could do was fill me with pain medications and anti-inflammatories.  The hot sweats were starting; actually it was more total body sweats yet I was freezing cold. My kidneys were working overtime.

Upon the first discharge from the hospital I got dizzy and fell onto the floor so they kept me another night. They diagnosed muscle-skeletal pain and heart problems due to the Lupron. Day by day different symptoms arrived, that was only the beginning of months of hell that followed for me.

When I stood up my skin felt so heavy it felt like it was falling off my body.

I had muscle-skeletal pain throughout my whole body, esp. the rib and breast bones.

Dyspnea, difficulty breathing.

Body sweats and chills, ghostly-white complexion.

Shrieking skull pain, migraine on right side of head.

I had huge cramps throughout my legs, pain in lower, outside, right leg.

Breast pain, loss of sexual desire (well who could think about sex with all this going on???)

Cold body, temperature 93.3 F

Low heart rate or racing heart.

Stomach swelled up, dehydrated, excessive thirst.

Throat swelled, feeling of choking.

Bowels quit working, kidneys working overtime.

Numb cheeks and limbs.

Visual disturbances, right eye teared constantly.

Nausea, dizziness, shakes.

Spinal tremors, irritability, nervousness.

Sore teeth, left jaw pain.

Cardiac arrhythmia, palpitations.

Insomnia.

Lower back pain.

Intensified rash and swollen lymph nodes.

Every evening at 8 pm my throat would swell and I could actually feel the serum pump out of my throat down into my chest, then throughout my body. The chest and breast pain would increase, my heart would start pumping wildly, my stomach would ache, cramping would increase, body sweats, cold body, and total exhaustion would set in.

I had to spray my entire mid section with muscle pain spray for weeks on end because the drugs didn’t even touch the pain. The horror went on day after day after week after week which turned into months. My Lupus and Fibromyalgia were flaring big time by now. I was gray in color and totally lifeless and I felt like I was going to die. It was the darkest time of my life.

After calling the Doctor who prescribed the Lupron to me, he sent me away saying, go see a cardiologist, there is no way Lupron would do that. It took over 3 months for the drug to quit the “flare effects: and 169 days to be eliminated (supposedly, according to science! I think it is still in my ribs as I have severe rib pain to this day), many natural remedies and 6 months for menstruation to return. Now all that was left was the damage. I also broke two teeth on Lupron.

No one had an antidote to stop this drug from terrorizing my body, so I took my dying body to a Naturopathic Doctor. She put me on some homeopathic medicines and herbals right away and miraculously she took that overwhelming feeling of death away. She said I was grey in color when I came in and that was almost 2 months after the shock set in.

I got my internal orans tested from electro dermal screening and they showed severe stress on all my internal organs, especially the heart, gallbladder, lymphatics, kidneys, bladder, thyroid, liver, adrenals and central nervous system. This was a direct result from the Lupron.

It totally devastated me and my family. Never again! I am going to continue to see a Naturopathic Doctor. She took away the numbness in my cheeks, the swelling in my hands, the shrieking skull pain, the dizziness, the total exhaustion, the rash is clearing up, I have some colour back and some energy.

I still have a long way to go but she helped me out of the severe stress that Lupron put me in. I have seen enough improvement to convince me, Naturopathic medicine is the only way out of a major adverse drug reaction or perhaps any major health crisis. I know who’s hands I feel safe in now.

Isn’t it amazing that they are so willing to pay $1188.00 (times two as it was only half the prescription, I opted out for round 2!)

God, I forgot how ill it made me. I am not a doctor, or a lawyer and this drug is approved by the FDA but not in my lifetime would I recommend it to any human. I actually would warn anyone not to use Lupron, but that is just my opinion through a very bad experience! It’s your body!

This was approved years ago by TAP, they had multi million dollar fines from it, so I suspect these are new companies that want to get in on the sales with this drug too. I think we will be hearing more people being prescribed this drug again. How can the FDA approve

I also would like to note that the cyst was still there after all was said and done. It was the herbals that took the cysts away. Now I believe that I could have avoided surgery when I was 18 as well.

I get the willies through my body when I see or hear the name Lupron. I will write this article but I won’t be reading it again, I just wanted other to know that you could experience side effects. When I was part of the Lupron victims website (10,000+ victims), there was a few deaths as well as heart attacks and stokes beside the multi symptoms and serious organ involvement from thousands of women as well as men. It is a drug given to men for prostrate cancer as well so you might want to check it out too guys. See http://www.lupronvictimshub.com/deaths.html for a long list of male deaths after taking Lupron.

http://www.fda.gov/Drugs/NewsEvents/UCM130961

January 20, 2011

  • DaTscan42 (ioflupane I 123) Injection, GE Healthcare, Approval
  • Eligard43 (leuprolide acetate) Subcutaneous Injection, sanofi-aventis U.S., LLC, Labeling Revision
  • Lupron44 (leuprolide acetate) Injection, Abbott Laboratories, Labeling Revision
  • Lupron Depot45 (leuprolide acetate) Injection, Abbott Laboratories, Labeling Revision
  • Lupron Depot46 (leuprolide acedate) Injectioon, Abbott Laboratories, Labeling Revision
  • Nithiodote47 (sodium nitrite and sodium thiosulfate) Injection, Hope Pharmaceuticals, Approval
  • Trelstar Depot48 (triptorelin palmoate) Intramuscular Injection, Watson Laboratories, Inc., Labeling Revision
  • Vantas49 (histrelin acetate) Subcutaneous Implant, Endo Pharmaceuticals Solutions, Inc., Labeling Revision
  • Viadur50 (leuprolide acetate) Implant, Johnson & Johnson Pharmaceutical Research and Development, LLC, Labeling Revision
  • Zoladex51(goserelin acetate) Implant, AstraZeneca Pharmaceuticals, LP, Labeling Revision
  • Zoladex52 (goserelin acetate) Implant, AstraZeneca Pharmaceuticals, LP, Labeling Revision

Read more other articles on Lupron:

Despite these many risks and negative experiences, manufacturers of leuprolide acetate have continued to market the drug for existing and new uses — most notably, as a treatment for prostate cancer. But a former U.S. Food and Drug Administration medical officer has said that Lupron’s manufacturer, TAP Pharmaceuticals, did not study the drug adequately before or after introducing it to the market, and he alleged that the company hid what it knew about risks of bone density loss, generalized pain, headaches, fluid retention, depression, and immune and nervous system problems, including spinal fracture, convulsions and paralysis.

My Doctor wanted me to go on Lyrica, the new drug treatment of choice now for Fibromyalgia. Isn’t it ironic that one of the side effects are muscle problems, muscle pain, soreness, or weakness, so if this is a daily occurrence for people with Fibromyalgia, how would one know? What scares me was the list of side effect LYRICA may cause such as suicidal thoughts and serious, even life-threatening, allergic reactions. Once you get a life threatening reaction to a drug, you tend to inquire about ALL the side effects of the drug they are prescribing to you.

Article from:

http://lyrica.com/fibromyalgia_sideeffects.aspx

LYRICA (LEER-i-kah) (pregabalin)
Capsules and Oral Solution, CV
Read this Medication Guide before you start taking LYRICA and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. If you have any questions about LYRICA, ask your healthcare provider or pharmacist.

What is the most important information I should know about LYRICA?
1. LYRICA may cause serious, even life-threatening, allergic reactions.
Stop taking LYRICA and call your healthcare provider right away if you have any of these signs of a serious allergic reaction:

– swelling of your face, mouth, lips, gums, tongue, throat or neck

– trouble breathing

– rash, hives (raised bumps) or blisters
2. Like other antiepileptic drugs, LYRICA may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.
Call a healthcare provider right away if you have any of these symptoms,
especially if they are new, worse, or worry you:

– thoughts about suicide or dying

– attempts to commit suicide

– new or worse depression

– new or worse anxiety

– feeling agitated or restless

– panic attacks

– trouble sleeping (insomnia)

– new or worse irritability

– acting aggressive, being angry, or violent

– acting on dangerous impulses

– an extreme increase in activity and talking (mania)

– other unusual changes in behavior or mood

If you have suicidal thoughts or actions, do not stop LYRICA without first talking to a healthcare provider.

Stopping LYRICA suddenly can cause serious problems.

– Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.
How can I watch for early symptoms of suicidal thoughts and actions?
– Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.

– Keep all follow-up visits with your healthcare provider as scheduled.

– Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

3. LYRICA may cause swelling of your hands, legs and feet. This swelling can be a serious problem for people with heart problems.

4. LYRICA may cause dizziness and sleepiness.
Do not drive a car, work with machines, or do other dangerous activities until you know how LYRICA affects you. Ask your healthcare provider about when it will be okay to do these activities.

What is LYRICA?
LYRICA is a prescription medicine used in adults, 18 years and older, to treat:
– pain from damaged nerves (neuropathic pain) that happens with diabetes
– pain from damaged nerves (neuropathic pain) that follows healing of shingles
– partial seizures when taken together with other seizure medicines
– fibromyalgia (pain all over your body)
LYRICA has not been studied in children under 18 years of age.
Who Should Not Take LYRICA?
Do not take LYRICA if you are allergic to pregabalin or any of the ingredients in LYRICA.

What should I tell my healthcare provider before taking LYRICA?
Before taking LYRICA, tell your healthcare provider about all your medical conditions, including if you:
– have or have had depression, mood problems or suicidal thoughts or behavior
– have kidney problems or get kidney dialysis
– have heart problems including heart failure
– have a bleeding problem or a low blood platelet count
– have abused prescription medicines, street drugs, or alcohol in the past
– have ever had swelling of your face, mouth, tongue, lips, gums, neck, or throat (angioedema)
plan to father a child. Animal studies have shown that pregabalin, the activeingredient in LYRICA, made male animals less fertile and caused sperm to change. Also, in animal studies, birth defects were seen in the offspring (babies) of male animals treated with pregabalin. It is not known if these problems can happen in people who take LYRICA.
are pregnant or plan to become pregnant. It is not known if LYRICA will harm your unborn baby. You and your healthcare provider will have to decide if you should take LYRICA while you are pregnant. If you become pregnant while taking LYRICA, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy.
– are breastfeeding. It is not known if LYRICA passes into breast milk and if it can harm your baby. You and your healthcare provider should discuss whether you should take LYRICA or breast-feed, but you should not do both. Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins or herbal supplements. LYRICA and other medicines may affect each other causing side effects. Especially tell your healthcare provider if you take:
angiotensin converting enzyme (ACE) inhibitors, which are used to treat many conditions, including high blood pressure. You may have a higher chance for swelling and hives if these medicines are taken with LYRICA.
Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone) for diabetes. You may have a higher chance of weight gain or swelling of your hands or feet if these medicines are taken with LYRICA.
– any narcotic pain medicine (such as oxycodone), tranquilizers or medicines for anxiety (such as lorazepam). You may have a higher chance for dizziness and sleepiness if these medicines are taken with LYRICA.
any medicines that make you sleepy
Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist each time you get a new medicine. Do not start a new medicine without talking with your healthcare provider.
How should I take LYRICA?
– Take LYRICA exactly as prescribed. Your healthcare provider will tell you how much LYRICA to take and when to take it. Take LYRICA at the same times each day.
– LYRICA may be taken with or without food.
– Your healthcare provider may change your dose. Do not change your dose without talking to your healthcare provider.
– Do not stop taking LYRICA without talking to your healthcare provider. If you stop taking LYRICA suddenly you may have headaches, nausea, diarrhea or trouble sleeping. If you have epilepsy and you stop taking LYRICA suddenly, you
may have seizures more often. Talk with your healthcare provider about how to stop LYRICA slowly.
– If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take two doses at the same time.
– If you take too much LYRICA, call your healthcare provider or poison control center, or go to the nearest emergency room right away.
What should I avoid while taking LYRICA?
– Do not drive a car, work with machines, or do other dangerous activities until you know how LYRICA affects you.
– Do not drink alcohol while taking LYRICA. LYRICA and alcohol can affect each other and increase side effects such as sleepiness and dizziness.
What are the possible side effects of LYRICA?
LYRICA may cause serious side effects, including:

muscle problems, muscle pain, soreness, or weakness. If you have these symptoms, especially if you feel sick and have a fever, tell your healthcare provider right away.

problems with your eyesight, including blurry vision. Call your healthcare provider if you have any changes in your eyesight.

weight gain. If you have diabetes, weight gain may affect the management of your diabetes. Weight gain can also be a serious problem for people with heart problems.

feeling “high”

The most common side effects of LYRICA are:
– dizziness

– blurry vision

– weight gain

– sleepiness

– trouble concentrating

– swelling of hands and feet

– dry mouth
LYRICA caused skin sores in animal studies. Skin sores did not happen in studies in people. If you have diabetes, you should pay attention to your skin while taking LYRICA and tell your healthcare provider about any sores or skin problems. Tell your healthcare provider about any side effect that bothers you or that does not go away. These are not all the possible side effects of LYRICA. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store LYRICA?
– Store LYRICA capsules and oral solution at room temperature, 59oF to 86°F (15oC to 30°C) in its original package.
– LYRICA Oral Solution must be used within 45 days of first opening the bottle.
– Safely throw away any LYRICA that is out of date or no longer needed.
– Keep LYRICA and all medicines out of the reach of children.

You can also visit the LYRICA website at www.LYRICA.com or call 1-866-459-7422 (1-866-4LYRICA).
What are the ingredients In LYRICA?
Active ingredient: pregabalin
Inactive ingredients:
LYRICA capsules: lactose monohydrate, cornstarch, talc
Capsule shell: gelatin and titanium dioxide; Orange capsule shell: red iron oxide; White capsule shell: sodium lauryl sulfate, colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. Imprinting ink: shellac, black iron oxide, propylene glycol, potassium hydroxide.
LYRICA oral solut on: methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water.
This Medication Guide has been approved by the U.S. Food and Drug Administration.

Capsules manufactured by:

Pfizer Pharmaceuticals LLC
Vega Baja, PR 00694
Oral Solution manufactured by:
Pfizer Inc.
Kalamazoo, MI 49001