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A Rational Biological Source of Pain in the Skin of Patients with Fibromyalgia

A Science Breakthrough To Identifying Pain of Fibromyalgia is Real

Fibromyalgia Is Not All In Your Head, New Research Confirms

Hallelujah! Shout it from the roof tops, scientists have found a possible explanation for the pain of Fibromyalgia!!! This will give some respect back to the sufferers who have been through cynicism and disbelief!

Researchers discover a rational biological source of pain in the skin of patients with fibromyalgia.

Albany Medical Center neurologist, Dr Rice 

Pain specialist Dr. Charles EArgoffthe study primary investigator

Collaborators 

Dr. James Wymer 
also at Albany Medical College and 

Dr. James Storey 
of Upstate Clinical Research Associates in Albany, NY

Clinical research proposals were funded by Forest Laboratories and Eli Lilly. 


the AV shunts in the hand are unique in that they create a bypass of the capillary bed for the major purpose of regulating body temperature.

A Thermostat for the Skin

In humans, these types of shunts are unique to the palms of our hands and soles of our feet which work like the radiator in a car

under warm conditions, the shunts close down to force blood into the capillaries at the surface of the skin in order to radiate heat from the body, and our hands get sweaty

under cold conditions, the shunts open wide allowing blood to bypass the capillaries in order to conserve heat, and our hands get cold

According to Dr. Albrecht, the excess sensory innervations may itself explain why fibromyalgia patients typically have especially tender and painful hands.

In addition, since the sensory fibers are responsible for opening the shunts, they would become particularly active under cold conditions, which are generally very bothersome to fibromyalgia patients.

A role in regulating blood flow throughout the body

Although they are mostly limited to the hands and feet, the shunts likely have another important function which could account for the widespread deep pain, achiness, and fatigue that occurs in fibromyalgia patients.

“In addition to involvement in temperature regulation, an enormous proportion of our blood flow normally goes to our hands and feet. Far more than is needed for their metabolism” noted Dr. Rice.

– the hands and the feet act as a reservoir from which blood flow can be diverted to other tissues of the body, such as muscles when we begin to exercise. Therefore, the pathology discovered among these shunts in the hands could be interfering with blood flow to the muscles throughout the body.

this mismanaged blood flow could be the source of muscular pain and achiness, and the sense of fatigue which are thought to be due to a build-up of lactic acid and low levels of inflammation in fibromyalgia patients.

– this, in turn, could contribute to the hyperactvity in the brain

alterations of normal blood flow may underlie other fibromyalgia symptoms, such as non-restful sleep or cognitive dysfunctions.

“The data do appear to fit with other published evidence demonstrating blood flow alterations to higher brain centers and the cerebral cortex of fibromyalgia patients” Dr Rice stated.

See diagram and read the full story at:

http://www.intidyn.com/Newsroom/article-0009.html

The Science

US National Library of Medicine National institute of Health


Pain Med.
 2013
Jun;14(6):895-915. doi: 10.1111/pme.12139. Epub 2013 May 20.

Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole-Venule
Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue

Source


Integrated Tissue Dynamics, LLC, Rensselaer, New York, USA; Center for


Neuropharmacology & Neuroscience, Albany Medical College, Albany, New York


USA
.

CONCLUSIONS:

– the excessive sensory innervation to the glabrous skin AVS is a likely

source of severe pain and tenderness in the hands of FM patients

– importantly, glabrous AVS regulate blood flow to the skin in humans for

thermoregulation and tother tissues such as skeletal muscle during periods of increased metabolic demand

– therefore, blood flow dysregulation as a result of excessive innervation to AVS would likely contribute to the widespread deep pain and fatigue of FM

– SNRI compounds may provide partial therapeutic benefit by enhancing the impact of sympathetically mediated inhibitory modulation of the excess sensory innervation

Wiley Periodicals, Inc.

PMID: 23691965 

My opinioin

So there is the science that they found to confirm Fibromyalgia sufferers are having “real pain”.

Finally! Do you feel a sense of relief? I don’t. The study was funded by the drug companies and they plan to find another drug to help kill the pain.

Is this just a symptom or a result of another cause?

I want to find the reason the shunts are not working properly, how about you?

I am going to return to this statement from above: this mismanaged blood flow could be the source of muscular pain and achiness, and the sense of fatigue which are thought to be due to a build-up of lactic acid and low levels of inflammation in fibromyalgia patients

So I am going to work on reducing or eliminating high lactic acid and inflammatory foods. My new book deals with inflammatory foods so it will be a big help for anyone seeking an alternative way to dealing with your pain. It will be released soon! Stay tuned for help on how to avoid prescriptions. Because I care!

http://naturalpainreliefforfibromyalgia.com/937


http://naturalpainreliefforfibromyalgia.com/1549

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